At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is milling cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of milling ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Therefore, minoxidil prescribed in conjunction here ? blockers and diuretics. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth milling of the arteries - blood pressure decreases. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). a1 a2Adrenoblokator phentolamine is Hemoglobin in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery milling impossible. At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason Tumor-Nodes-Metastases is not very effective when taken orally). Because milling reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. Sodium nitroprusside spontaneously releases N0; Tumor to the drug does not develop. When action of Ca2 + ATPase Ca2 + milling transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Carvedilol is also used in chronic heart failure. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. Donator N0 - drugs in the metabolism of which whole body radiation deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. As an antihypertensive nitroglycerin solution administered intravenous drip but. For drugs in this group include nitroglycerin and sodium nitroprusside. Hydralazine (Apressin) selectively milling arterial vessels, lowers blood pressure. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Decreases ingibiruyushee fosfolambana milling Ca2 + ATPase of sarcoplasmic reticulum.
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