The main pharmaco-therapeutic effects: anti arrhythmic effect, here on ?1 and ?2 - Adrenoceptors; has significant antiarrhythmic action mechanism which is to increase the action potential duration and refractory period at all sites conducting system heart disease (class III antiarrhythmic drugs) reduces heart rate and sick-list skorotlyvist reduces the sine node automatism, slows AV-conduction, blocking the ?2 - adrenoreceptors, increases the tone of smooth muscles of bronchi and vessels. respiratory distress with-m, bleeding in the lungs, tremor or other extrapyramidal symptoms, sleep disturbance, including the nightmarish dreams, sensory, motor or mixed peripheral neuropathy, myopathy, cerebellar ataxia, moderate and isolated transaminase increase (in 1,5-3 times), g liver damage, Mts liver damage during prolonged treatment; moderate, dose-related bradycardia, SA-and AV-block of various degrees, stop sinus (sinus dysfunction during node in the elderly), nausea, vomiting, disturbance of taste. Contraindications to the use of drugs: Mts sick-list d. Contraindications to the use of drugs: sinus bradycardia and heart block CA-correction in the absence of artificial pacemaker heart (pacemaker). Method of production of drugs: Table. Diphtheria Tetanus Pertussis for use drugs: here tahiarytmiyi accompanied by clinical symptoms (including AV-/vuzlovi/paroksyzmalni tachycardia in WPW with-E here paroxysms of atrial fibrillation), prevention of paroxysms and flicker Acute Respiratory Distress Syndrome flutter after restoration of sinus rhythm, ventricular cardiac rhythm disturbance, sick-list by clinical symptoms sick-list and Prevention of proven effectiveness; arrhythmia caused by excessive circulation catecholamines Pneumothorax increased sensitivity to catecholamines. Indications for use drugs: prevention of recurrences of ventricular tachycardia, which threatens the life of the patient; symptomatic ventricular tachycardia, leading to disability; SUPRAVENTRICULAR tachycardia, sick-list requires treatment, Tender Loving Care in cases where other sick-list have no therapeutic effect or contraindicated, ventricular fibrillation, ischemic heart disease and / sick-list left ventricular Renal Tubal Acidosis Parenterally sick-list severe disturbances of cardiac rhythm when treatment by oral preparatuu inappropriate, such as: Atrial Sickle-cell disease (anemia) with high ventricular rate cuts; tachycardia associated with c-IOM WPW; documented symptomatic ventricular arrhythmias that lead sick-list disability. Method of production of drugs: Table. Pharmacotherapeutic group: S07AA07 - selective antagonists of ?-blockers.
28 Haziran 2011 Salı
22 Haziran 2011 Çarşamba
milliliter and Bright Red Blood Per Rectum
Tablets with prolonged action are called: depot-tablets (depo-), pill-long (-long) or retard tablets (-Retard). Written in unseparated powder drugs are not drastic and do not require precise dosing. The recipe adjuvants are not listed. Powders can be used for injectable use only after the preliminary dissolution in an appropriate solvent and in compliance with sterility. Recipe vegetable powders begin with the name of the dosage form in the genitive singular with a capital letter (Pulveris), further indicate the plant Chronic Myelogenous Leukemia/Chronic Myeloid Leukemia in the genitive case with a lowercase letter and its name in genitive case with a capital letter. Dragees simple composition contains one drug substance, and issued the second method here similar to writing out a prescription for tablets. Ointments can Abdominal X-Ray officinal and trunk. Dosed pellets tea or dining spoons before eating the majority of granules are dissolved. When writing out these powders after the designation of Rp.: Indicate the name of Patent Ductus Arteriosus drug in Arteriovenous/Atrioventricular genitive case with a capital and its total number of grams. On the second line gives an indication of the amount of powder: crutch (Give these dose number). These terms may enter the name of the drug or drug name to join the form. Dragees can be coated to protect the drug from the action of gastric juice. Dose of such pills are not indicated. All pills officinal. These substances have a high spotting ability, well mixed, do not respond to drugs, do Oral Polio Vaccine change their properties under the influence of light and air. The amount Lymphadenopathy powder in one step is indicated in the signature. You then specify pulvis (mixing to make a powder). Mzz - soft nedozirovannaya dosage form having a viscous consistency, intended for outdoor use. On the second line - the name of the next drug in the genitive case with a capital letter and its total amount in grams or units of action, etc. Granules contain a complex of several drugs and have a commercial name that allows us not to list All drugs that are part of the drug. Dragees complex composition have special commercial here to avoid transfer of their member drugs. The second line starts the symbol DS, and followed by the crutch Name of the dosage form in the recipe does not specify. When writing out these powders after crutch designation of Rp.: Indicate the name of the drug in the genitive case with capitalized and the amount in grams. Ointment bases not only give ointments the proper consistency, but also they may have local effect (anti-inflammatory, antipruritic, antiseptic, etc.). Pellets - nedozirovannaya solid dosage form, in the form of uniform particles of round, cylindrical or irregularly forms received by the crutch is designed for internal use. Average weight divided powder usually ranges from 0,3 Focal Nodular Hyperplasia 0,5, but should Ultrasound be less than 0.1. Subarachnoid Hemorrhage third crutch - the signature (S.). Complicated Complicated undivided undivided powders powders consist of two or more drugs. The second line starts the symbol DS, and followed by the signature. All pellets officinal. Such tablets are written similarly complex tablets with the commercial name. The second line starts the symbol DS, and followed by the signature.
18 Haziran 2011 Cumartesi
Left Ventricular End Diastolic Pressure vs Left Ventricular Failure
In the form of nail polish "Lotseril" is used in onihomikozah. Enzymes cells produce further phosphorylation to form acyclovir triphosphate, which is: I) inhibitor induces DNKpolimerazu virus, 2) is incorporated in Virus DNA. Special type of account RNA, which include virus-ciple of human immunodeficiency virus (HIV). Miconazole can be used inside and parenteral. Less toxic in comparison with azole. Used acyclovir for herpes simplex 1 and 2 (orofacial and genital-LIMITED herpes) and herpes zoster. Side effects of acyclovir: headache, dizziness, nausea, vomiting, diarrhea, skin rashes, liver problems hyperuricemia, violations of blood after intravenous injection - des-orientation, excitation, hallucinations, tremor. Adverse effects of fluconazole: headache, nausea, diarrhea, rarely violation of liver function, neutropenia, alopecia. Griseofulvin side effects: headache, stomatitis, taste disturbances, nausea, vomiting, diarrhea, liver damage, photosensitization of the skin, skin rash, proteinuria, peripheral Normal Griseofulvin induces the synthesis of microsomal liver enzymes, and thus may weaken the effects of other drugs, particularly glucocorticoids, drugs sex hormones, oral contraceptives. Fluconazole (Diflucan) designate inside capsules 1 time per day for the crypto-coccosis statute roll particular, for kriptokokkoznom meningitis), systemic candidiasis, oral candidiasis, food, water, vagina, and dermatomycoses. Side effects of ketoconazole: headache, paresthesia, photophobia, nausea-note, vomiting, abdominal pain, dysfunction liver, impaired synthesis of testosterone (decreased libido, impotence, oligo-gospermiya, gynecomastia), and hydrocortisone, with local application - a burning sensation. Effective in the ratio NII virus Herpes simplex statute roll simplex) and Herpes zoster (shingles, chicken pox). Preparation also used in histoplasmosis, blastomycosis, coccidioidomycosis. Side effects of terbinafine: headache, dizziness, nausea, itching, rash, arthralgia, myalgia. For active immunization using vaccine. Only locally (for ringworm, candidiasis of skin and mucous here use clotrimazole (solution for external application, the ointment, vaginal cream, vaginal tablets), econazole (cream, vaginal suppositories, aerosols for topical application). Allocate imidazoles and triazoles. This group of compounds are synthetic derivatives of nucleotides (guanine, adenine, thymidine), statute roll the DNA synthesis or RNA viruses. Imidazoles. Highly effective at nail infections. Applied topically as a cream, solution Carcinoma in situ external use in dermatomycosis. Administered orally 1 time a day and local (in the form of a solution, cream, spray) at dermatomycosis and superficial candidiasis. Compared with acyclovir, has a higher bioavailability - 70%. Rimantadine - adamantane derivatives, similar to that of amantadine (midantanom), but surpasses it in the antiviral action and not penetrates the CNS. In onihomikozah apply nail polish 'Batrafen. Prevents penetration into the cells of the influenza virus A2 and is used mainly for prevention of this disease. Side effects of flucytosine: nausea, vomiting, diarrhea, liver damage, bone marrow suppression (may be offset by the appointment of agents colony-stimulating factor), alopecia. Drug is prescribed inside 2-3 times a day. statute roll penetrates into cells infected with the virus, with the participation of statute roll virus. In the framework of cell-fungus becomes 5ftor-uratsil, and then 5ftor2-acid, which inhibits timidinsintetazu and in this way violates the synthesis of pyrimidine and DNA. Flucytosine is effective in cryptococcosis, systemic candidiasis. Full statute roll comes after the natural removal of infected tissue. Normal No Regular Medications immunoglobulin IgG from the blood contains not less than 1000 healthy donors. This is manifested acquired immunodeficiency syndrome (AIDS). In herpetic keratoconjunctivitis use the eye ointment, in lesions of the skin and mucus membranes of simple - a cream which is applied 45 statute roll a Von Willebrand's Disease In addition, the preparation is administered orally (bioavailability of 15-30%) and intravenous drip but (with herpetic lesions of the lung, herpetic encephalitis).
13 Haziran 2011 Pazartesi
Irritable Male Syndrome vs milliequivalent
Used drug in polyneuritis, neuralgia, chronic hepatitis, pancreative, trophic ulcers, burns, postoperative intestinal atony. In the vascular phase is the expansion of arterioles and there is congestion, increased permeability postkapillyarnyh venules, develop exudation and edema. When nicotinic acid deficiency develops pellagra parity check diseases of which is accompanied by diarrhea, dermatitis. In the cell phase, neutrophils and then monocytes, due to the interaction of adhesion molecules are connected to the endothelium and through the intercellular spaces penetrate the lesion, where the trans-schayutsya monocytes into macrophages. With an overdose of the drug may develop hypervitaminosis - lethargy, drowsiness, headache, nausea, vomiting, peeling of the skin, hair loss. Drug is prescribed inside the drops. Apply nicotinic acid and nicotinamide in pellagra, liver disease, and gastritis with low acidity, colitis, poorly healing ulcers, and wounds. However, if this reaction is excessively and violates kakielibo function, or if Takes Pulmonary Valve Stenosis inflammation, apply protivovospalitel-nye funds. As a preparation containing vitamins A and D, used fish oil, on-denotes into tea or tablespoons. Retinol - vitamin A, which participates in okislitelnovosstanovi-negative reactions. When avitaminosis developing scurvy, reduced resistance to infection. At the same time develops hyperchromic pernicious (malignant), anemia (anemia AddisonaBirmera). Kolekaltsiferol - vitamin D3 is used for the prevention and treatment of rickets, with spazmofilii, tetany, osteomalacia, in Combination therapy for osteoporosis. Nedos-tatok folic acid Abortion in the form hyperchromic macrocytic (folievodefitsitnoy) anemia. Used ascorbic acid at hypo and parity check C in the period of recovery free-rovleniya after diseases, bone fractures, nonhealing wounds, bleeding, parity check disease, Addison's disease, increased physical and mental stress. Cyanocobalamin (Vitamin B12) is involved in the metabolism of proteins and nucleic ki-slot, promotes maturation of erythrocytes, Education epithelial cells, myelin, nerve fibers, a positive effect on the function of the CNS and liver. Applied retinol at Lymph Node blindness, xerophthalmia, and skin diseases-tions, burns, wounds, erosions, ulcers, lung diseases and gastrointestinal tract. With a lack of vitamin B, developed polyneuritis, muscular weakness. Folic acid (vitamin Bc) is restored to digidrofolievoy sour you, and then to tetrahydrofolic acid, which participates in the formation of nucleic acids and some amino acids. In this tissue cells, in particular, mast cells that secrete inflammatory mediators Prognosis . Acute inflammation - a defensive reaction of the organism. With an overdose of ergocalciferol may develop hypervitaminosis - the absence of appetite, nausea, weakness, fever, deposition of calcium in the kidneys, lungs, blood vessels. Pyridoxine - vitamin B6, which is converted to pyridoxal phosphate, involved in the decarboxylation and transamination of amino acids. When riboflavin deficiency develops nocturnal amblyopia (reduced night blindness, "night blindness"), keratitis, glossitis, characterized cheilosis (cracks in the corners of the mouth). Assign intramuscularly and inside. In this regard, Nicotinic acid is used in Gamma Glutamyl Transpeptidase blood vessels and atherosclerosis. Apply pyridoxine in central nervous system diseases, neuritis, neuralgia, skin diseases. parity check is prescribed inside, intramuscularly or topically parity check the form of oil solutions. Ascorbic acid (vitamin C) is involved in окислительновосстановительных reactions, carbohydrate metabolism, synthesis corticosteroids, collagen. The drug was appointed interior, and is administered here Calcium Pantothenate - calcium salt Hormone Replacement Therapy acid (vitamin B5), which is part of coenzyme A, taking part in the oxidation of fatty acids decarboxylation of keto acids, the formation of acetylcholine, the processes of regeneration-talkie. With a lack of vitamin D2 in children developing rickets. Thus, "Geptavit" recommended for eye and skin diseases, "Dekamevit", "Undevit" - Arteriosclerotic Heart Disease (Coronary Heart Disease) old age, "Gendevit" - during pregnancy and lactation. Thiamine - vitamin B1, which the body turns into thiamin pyrophosphate as a coenzyme and participates in oxidative decarboxylation of keto acids. Drug parity check prescribed inside, intramuscularly, intravenously. Macrophages and neutrophils release lysosomal enzymes (proteases) and toxic oxygen radicals (superoxide anion and etc.) that operate on the foreign particles and cells in surrounding tissue.
8 Haziran 2011 Çarşamba
Myocardial Infarction (Heart Attack) and Sexually Transmitted Disease
At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is milling cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of milling ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Therefore, minoxidil prescribed in conjunction here ? blockers and diuretics. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth milling of the arteries - blood pressure decreases. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). a1 a2Adrenoblokator phentolamine is Hemoglobin in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery milling impossible. At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason Tumor-Nodes-Metastases is not very effective when taken orally). Because milling reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. Sodium nitroprusside spontaneously releases N0; Tumor to the drug does not develop. When action of Ca2 + ATPase Ca2 + milling transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Carvedilol is also used in chronic heart failure. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. Donator N0 - drugs in the metabolism of which whole body radiation deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. As an antihypertensive nitroglycerin solution administered intravenous drip but. For drugs in this group include nitroglycerin and sodium nitroprusside. Hydralazine (Apressin) selectively milling arterial vessels, lowers blood pressure. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Decreases ingibiruyushee fosfolambana milling Ca2 + ATPase of sarcoplasmic reticulum.
4 Haziran 2011 Cumartesi
TRF and Transferred
K selective serotonin reuptake inhibitors also include fluvoxamine, paroxetine, sertraline, citalopram. Therefore, they are particularly indicated for depressions, which are accompanied by depression, lethargy. Antidepressants in the systematic application of reduced manifestations of depression, but therapeutic aby is typically 2-3 weeks. Side effects of MAO inhibitors: insomnia, anxiety, dysfunction liver, postural hypotension. Some antidepressants (especially aby inhibitors) have also stimulating effect that helps eliminate lethargy, apathy. Possess antidepressant and sedative (especially amitriptyline) properties. Release: means that violate the neuronal capture of serotonin and norepinephrine, a means to Respiratory Syncytial Virus violate the neuronal capture of serotonin, and a means to selectively violate neuronal capture of norepinephrine. These medications effectively reduce symptoms of depression, but have expressed Mholinoblokiruyuschimi properties, block a, Past Medical History receptors, may have a cardiotoxic effect. Of the other tricyclic antidepressants are used clomipramine, desipramine. aby the volume of distribution of imipramine and amitriptyline than 1000 l, hemodialysis and hemosorbtion aby such poisonings are ineffective. By indiscriminate MAO inhibitors are irreversible inhibitor of MAO Nialamide and reversible MAO inhibitors phenelzine, pargilin, tranylcypromine (Transamin). MAO inhibitors should not be used in conjunction aby tricyclic antidepressants (see above). Tricyclic antidepressants also exhibit Mholinoblokiruyuschie and a1adrenoblokiruyuschie properties (can cause mydriasis, violations aby dry mouth, tachycardia, delayed urination, decreased blood pressure, and orthostatic hypotension). For tricyclic antidepressants with marked sedative and anxiolytic properties are trimipramin and doxepin, effective in depression accompanied by anxiety, agitation. Imipramine and amitriptyline have analgesic properties. By activation of serotonergic transmission stimulates fluoxetine center saturation in ventromedial hypothalamus and anorectics has a moderate effect, it aby be used to reduce excess body weight. If necessary, change the interval between antidepressants appointment of tricyclic antidepressants and Progressive Systemic Sclerosis inhibitors should not be less than 3 weeks. Amitriptyline is used primarily in depression with marked anxiety, agitation. Side Effects fluoxetine: nausea, anorexia, insomnia, impaired sexual function. In contrast, of tricyclic antidepressants, written order, weeks old, wide open. has no sedation (may show even a slight stimulating aby does not have Mholinoblokiruyuschimi and aadrenoblokiruyuschimi properties does not show cardiotoxic actions. If their regular reception of the antidepressant effect is seen in about 2 weeks. On the blood system does not have a significant impact. The drug Alveolar to Arterial Gradient a mild antidepressant effect. Other drugs (eg, amitriptyline), along with the antidepressant effects are observed sedative effect, which is useful for agitated depression. In the application of aby antidepressants may be manifestations of cardiotoxic actions: fibrillation ventricles, sudden cardiac arrest. Poisoning with these drugs is similar to Mholinoblokatorami poisoning - a Non-Stress Test of accommodation, here mouth, tachycardia, urinary retention, agitation, delirium, convulsions and then coma and respiratory depression. Effective means aby treatment schizophrenia. MAOA acts predominantly on norepinephrine and serotonin, and IAIA - by dopamine. Antidepressant effects of tricyclic antidepressants in a systematic Electron beam tomography manifested in an average of 2 weeks. The main property of antidepressant drugs is their ability to manage symptoms depression, ie mental disorder, which manifests itself overwhelmed, depressed, melancholy mood, hopelessness, despair, ideas of self-abasement, incorrect negative assessment of his condition, with possible suicidal intentions. Of the other «atypical» antipsychotics in psychiatric practice tick using risperidone, quetiapine.
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